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@thesis{thesis, author={IKA MIRA PUSPITA SARI }, title ={PENGARUH EKSTRAK ETANOL UMBI UWI UNGU (DIOSCOREA ALATA) TERHADAP AKTIVITAS FAGOSITOSIS MAKROFAG PADA MENCIT (MUS MUSCULLUS) MODEL ALERGI}, year={2013}, url={https://etd.umy.ac.id/id/eprint/13649/}, abstract={Allergy is hypersensitivity induced by exposure to a particular antigen (allergen). The body's cellular immune response to allergens is characterized by an increase in phagocytic activity of macrophages. In vitro found that tuber Dioscorea alata has the effect of allergy. This study aims to determine the effect of Purple Yam Tuber ethanol extract to Macrophage Phagocytosis Activities in Allergy-Induced Mice. The research design was experimental in vivo animal test with post-test designonly control group design. The research subjects are 42 mice Balb/C male, ± 20gram weight, age 10-12 weeks, divided into six groups consisting of a negative control group, the ovalbumin (OVA) group, positive control group (antihistamine + ovalbumin), D. alata extract peroral dose of 0.31g, 0.62g and 1.24g/kg mm/day for 28 days and sensitized ovalbumin. Phagocyteactivity of macrophages from the number of measured macrophages can phagocytosis latex particles and the mean number of phagocyted latex particle by every macrophage under light microscopy. The results of statistical test showed the average number of macrophages and the amount of latex is not significant in any of the test group (p>0.05) but the average results ± SD showed a decrease. Extract dose groups 0.62g/kg mm/day showed decrease of more than the other test groups. From these results it can be concluded that the ethanol extract of purple yam tuber (Dioscorea alata) can affect on macrophage phagocytosis activities in allergy-induced mice.} }