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@thesis{thesis,
author={Dr. dr. Idham Jaya and W I L D A N A },
title ={ANALISIS KADAR MATRIX METALLOPROTEINASE-9
PADA PENDERITA CARCINOMA MAMMAE},
year={2012},
url={http://repository.unhas.ac.id/id/eprint/10498/},
abstract={WILDANA. Analisis Kadar Matrix Metalloproteinase-9 (MMP-9) pada
Penderita Carcinoma Mammae (Dibimbing oleh Uleng Bahrun dan
Mansyur Arif)
Penelitian ini bertujuan untuk menganalisis kadar MMP-9 serum pada
penderita carcinoma mammae.
Penelitian ini dilakukan di RSUP Dr. Wahidin Sudirohusodo dan RS. Ibnu
Sina Makassar. Metode peneitian yang digunakan adalah cross sectional.
Penelitian yang dilakukan selama bulan Desember 2011 sampai dengan
Februari 2012. Total sampel 56 orang, berumur antara 31 ? 68 tahun
dibagi menjadi dua kelompok yaitu stadium dini (stadium I dan II, n=12)
dan stadium lanjut (stadium III dan IV, n=44). Stadium lanjut kemudian
dibagi menjadi stadium lanjut lokal (stadium III, n=32) dan stadium
metastasis (stadium IV, n=12). Kadar MMP-9 diukur dengan metode
enzyme-linked immunosorbent assay (ELISA), menggunakan kit MMP-9
Quantikine dari R&D System (Minneapolis).
Hasil penelitian menunjukkan rerata kadar MMP-9 serum pada carcinoma
mammae stadium dini adalah 497,821 ng/mL dan pada stadium lanjut
822,158 ng/mL. Independent sample T test menunjukkan adanya
perbedaan bermakna kadar MMP-9 serum antara stadium dini dan
stadium lanjut. Rerata kadar MMP-9 serum pada stadium lanjut lokal
897,797 ng/mL dan stadium metastasis 684,006 ng/mL. Independent
sample T test menunjukkan tidak ada perbedaan yang bermakna antara
stadium lanjut lokal dan stadium metastasis. Kadar MMP-9 serum dapat
memberikan gambaran progresi Carcinoma mamma}
}
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