Uji aktivitas Antihiperglikemik Lipid Nanocarrier kombinasi fraksi etil asetat kayu manis (Cinnamomum burmannil) dan fraksi etil asetat pegagan (Centella asiatica) terhadap enzin alfa glukosidase
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Institusion
Universitas Ahmad Dahlan
Author
Pratiwi, Annisa
Subject
RM Therapeutics. Pharmacology
Datestamp
2024-05-31 03:07:09
Abstract :
Hyperglycemia is a major sign of a complex metabolic disease known as diabetes mellitus (DM). Cinnamon (Cinnamomum burmannii) and Centella asiatica (Centella asiatica) have antidiabetic activity, capable of lowering blood sugar levels by inhibiting the enzyme ?-glucosidase. The purpose of this study was to obtain a lipid nanocarrier combination of ethyl acetate fractions of cinnamon (Cinnamomum burmannii) and centella asiatica (Centella asiatica) which is expected to increase the inhibition of ?-glucosidase enzymes. This antihyperglycemic research uses the mechanism of inhibition of the enzyme ?-glucosidase, to determine the amount of inhibition that can be given by Lipid Nanocarrier combination of ethyl acetate fractions of cinnamon (Cinnamomum burmannii) and centella asiatica (Centella asiatica) against the enzyme ?-glucosidase. The method of inhibition of the enzyme ?-glucosidase used is carried out with slight modifications. Samples of cinnamon ethyl acetate fraction nanocarrier lipids, pegagan ethyl acetate fraction lipid nanocarriers and combination ethyl acetate fraction nanocarrier lipids were measured for absorbance using a UV-Vis spectrophotometer at a wavelength of 405 nm. Then, the percentage of sample inhibition is calculated using the absorbance value and the value of ?IC?_(50 )is calculated using the linear regression equation. The yield of ?IC?_(50 )lipid nanocarrier ethyl acetate fraction cinnamon, lipid nanocarrier fraction ethyl acetate centella asiatica and lipid nanocarrier fraction ethyl acetate combination respectively namely 4.54 ± 0.05 mg/mL; 3.13 ± 0.14. So, it can be concluded that lipid nanocarrier ethyl acetate fraction combination of cinnamon and gotu kola has enzyme inhibitory ability ?-glucosidase equivalent to acarbose compared to lipid nanocarrier ethyl acetate fraction lipid nanocarrier ethyl acetate fraction cinnamon and lipid nanocarrier ethyl acetate fraction gotu kola.
Hyperglycemia is a major sign of a complex metabolic disease known as diabetes mellitus (DM). Cinnamon (Cinnamomum burmannii) and Centella asiatica (Centella asiatica) have antidiabetic activity, capable of lowering blood sugar levels by inhibiting the enzyme ?-glucosidase. The purpose of this study was to obtain a lipid nanocarrier combination of ethyl acetate fractions of cinnamon (Cinnamomum burmannii) and centella asiatica (Centella asiatica) which is expected to increase the inhibition of ?-glucosidase enzymes. This antihyperglycemic research uses the mechanism of inhibition of the enzyme ?-glucosidase, to determine the amount of inhibition that can be given by Lipid Nanocarrier combination of ethyl acetate fractions of cinnamon (Cinnamomum burmannii) and centella asiatica (Centella asiatica) against the enzyme ?-glucosidase. The method of inhibition of the enzyme ?-glucosidase used is carried out with slight modifications. Samples of cinnamon ethyl acetate fraction nanocarrier lipids, pegagan ethyl acetate fraction lipid nanocarriers and combination ethyl acetate fraction nanocarrier lipids were measured for absorbance using a UV-Vis spectrophotometer at a wavelength of 405 nm. Then, the percentage of sample inhibition is calculated using the absorbance value and the value of ?IC?_(50 )is calculated using the linear regression equation. The yield of ?IC?_(50 )lipid nanocarrier ethyl acetate fraction cinnamon, lipid nanocarrier fraction ethyl acetate centella asiatica and lipid nanocarrier fraction ethyl acetate combination respectively namely 4.54 ± 0.05 mg/mL; 3.13 ± 0.14. So, it can be concluded that lipid nanocarrier ethyl acetate fraction combination of cinnamon and gotu kola has enzyme inhibitory ability ?-glucosidase equivalent to acarbose compared to lipid nanocarrier ethyl acetate fraction lipid nanocarrier ethyl acetate fraction cinnamon and lipid nanocarrier ethyl acetate fraction gotu kola.
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