EFFECTIVENESS TEST LEAF EXTRACT COMBINATION Noni (Morinda citrifolia L.)
EXTRACT SKIN FRUIT AND WATERMELON (Citrullus lanatus L.) ON BLOOD
GLUCOSE LEVELS AND WHITE MALE MICE
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Institusion
Universitas Pakuan
Author
Septian Dewi, Aprina
Effendi, E, Mulyati
Agus Setiani, Lusi
Effendi, E, Mulyati
Agus Setiani, Lusi
Subject
Ilmu Komputer
Datestamp
2022-09-03 17:22:40
Abstract :
ABSTRACT Diabetes Mellitus (DM) is one of the a type of chronic metabolic disorder characterized by blood glucose levels that exceed normal values. This study aims to determine the effectiveness of the combined dose of noni leaf extract and watermelon rind extract as a reduction in blood sugar levels in male white mice. As many as 35 test animals were used, which were divided into 7 experimental groups with each treatment consisting of 5 mice as replications. The treatment group consisted of: positive control (glibenclamide 0.65 mg / 20 g BW), negative control (CMC Na), dose 1 (noni leaf extract 32 mg / 20 g BW), dose 2 (watermelon rind extract 14 mg / 20 g BW), combination dose 3 (noni leaf extract 32 mg / 20 g BW : watermelon rind extract 14 mg / 20 g BW), combination dose 4 (noni leaf extract 32 mg / 20 g BW: watermelon rind extract 28 mg / 20 g BW), a combination dose of 5 (noni leaf extract 16 mg / 20 g BW: watermelon rind extract 28 mg / 20 g BW), then the test animals measured their blood sugar levels. The data obtained were then analyzed using a factorial randomized block design (RBD). Mice were treated according to the treatment group for 21 days until the blood sugar levels of the mice were normal, measurement of blood sugar levels was carried out on days 7, 14 and 21. The results showed that all treatment doses had activity to lower blood sugar levels. The combination of noni leaf extract at a dose of 32 mg / 20 gBB and watermelon rind extract 14 mg / 20 gBB with a duration of administration for 14 days is the most effective dose as a reduction in blood sugar levels with a percentage reduction of 61.57%. Key words: Diabetes Mellitus, Antidiabetic, Noni Leaf and Watermelon Rind.
ABSTRACT Diabetes Mellitus (DM) is one of the a type of chronic metabolic disorder characterized by blood glucose levels that exceed normal values. This study aims to determine the effectiveness of the combined dose of noni leaf extract and watermelon rind extract as a reduction in blood sugar levels in male white mice. As many as 35 test animals were used, which were divided into 7 experimental groups with each treatment consisting of 5 mice as replications. The treatment group consisted of: positive control (glibenclamide 0.65 mg / 20 g BW), negative control (CMC Na), dose 1 (noni leaf extract 32 mg / 20 g BW), dose 2 (watermelon rind extract 14 mg / 20 g BW), combination dose 3 (noni leaf extract 32 mg / 20 g BW : watermelon rind extract 14 mg / 20 g BW), combination dose 4 (noni leaf extract 32 mg / 20 g BW: watermelon rind extract 28 mg / 20 g BW), a combination dose of 5 (noni leaf extract 16 mg / 20 g BW: watermelon rind extract 28 mg / 20 g BW), then the test animals measured their blood sugar levels. The data obtained were then analyzed using a factorial randomized block design (RBD). Mice were treated according to the treatment group for 21 days until the blood sugar levels of the mice were normal, measurement of blood sugar levels was carried out on days 7, 14 and 21. The results showed that all treatment doses had activity to lower blood sugar levels. The combination of noni leaf extract at a dose of 32 mg / 20 gBB and watermelon rind extract 14 mg / 20 gBB with a duration of administration for 14 days is the most effective dose as a reduction in blood sugar levels with a percentage reduction of 61.57%. Key words: Diabetes Mellitus, Antidiabetic, Noni Leaf and Watermelon Rind.
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