SINTESIS DAN UJI TOKSISITAS KOMPLEKS Co(II) DENGAN LIGAN 2(KLOROFENIL)-4,5-DIFENIL-1H-IMIDAZOL
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Institusion
Institut Teknologi Sepuluh Nopember
Author
CANDRAWATI, IIN
Subject
QD Chemistry
Datestamp
2019-03-06 04:48:36
Abstract :
Senyawa kompleks Co(II) dengan ligan 2(4-klorofenil)-4,5-difenil-1H-imidazol telah berhasil disintesis menggunakan metode refluks. Rendemen senyawa kompleks yang dihasilkan sebesar 65,29%. Kristal senyawa kompleks yang dihasilkan berwarna ungu dan mempunyai panjang gelombang 445 nm. Berdasarkan analisa unsur CHN diperoleh hasil C=61,038%, H=5,174% dan N=6,779%. Hasil karakterisasi AAS diperoleh kadar ion logam Co(II)=7,146%. Berdasarkan nilai tersebut maka usulan struktur senyawa kompleks tersebut mempunyai geometri oktahedral dengan usulan rumus molekul Co(II)[2(4-klorofenil)-4,5-difenil-1H-Imidazol]2(H2O)4∙2H2O. Formula struktur tersebut didukung dengan hasil analisa TGA yang menunjukkan dekomposisi air kristal pada suhu 160,75-180,71 C dan dekomposisi air ligan pada suhu 216,15-263,18 C. Spektrofotometer FTIR menunjukkan adanya ikatan v(Co-N) dan v(Co-OH2) pada bilangan gelombang 503,44 cm-1 dan 419,57 cm-1. Uji toksisitas senyawa ini dilakukan dengan metode Brine Shrimp Lethality Test (BSLT) dan dihasilkan nilai toksisitas LC50 ligan 2(4-klorofenil)-4,5-difenil-1H-imidazol dan kompleks Co(II) sebesar 23,71 ppm dan 59,70 ppm. ==================================================================================================== Cobalt(II) complex compound with 2(4-chlorophenyl)-4,5-diphenyl-1H-imidazole ligand has been synthesized using reflux method. The yield of the complex is 65.29%. The violet crystal was absorbed at 445 nm. The complex was characterized by CHN elemental analyzer with the results C=61.038%, H=5.174% and N=6.779%. Characterization of metal ion by AAS obtained Co(II)=7.146%. Based on these values, the proposed structure of the complex compound is octahedral and the proposed molecular is Co(II)[2(4-chlorphenyl)-4,5-diphenyl-1H-Imidazoel]2(H2O)4∙2H2O. The structural formula is supported by the analysis of TGA that showed crystal water decomposition at 160.5-180.71 °C and ligand water decomposition at 216.15-263.18 °C. The IR spectrum showed the characteristic of v(Co-N) and v(Co-OH2) at 503.44cm-1 and 419.57 cm-1. Toxicity test was observed by Brine Shrimp Lethality Test (BSLT) method revealed the LC50 of the ligand and the complex are 23.71 ppm and 59.70 ppm.
Senyawa kompleks Co(II) dengan ligan 2(4-klorofenil)-4,5-difenil-1H-imidazol telah berhasil disintesis menggunakan metode refluks. Rendemen senyawa kompleks yang dihasilkan sebesar 65,29%. Kristal senyawa kompleks yang dihasilkan berwarna ungu dan mempunyai panjang gelombang 445 nm. Berdasarkan analisa unsur CHN diperoleh hasil C=61,038%, H=5,174% dan N=6,779%. Hasil karakterisasi AAS diperoleh kadar ion logam Co(II)=7,146%. Berdasarkan nilai tersebut maka usulan struktur senyawa kompleks tersebut mempunyai geometri oktahedral dengan usulan rumus molekul Co(II)[2(4-klorofenil)-4,5-difenil-1H-Imidazol]2(H2O)4∙2H2O. Formula struktur tersebut didukung dengan hasil analisa TGA yang menunjukkan dekomposisi air kristal pada suhu 160,75-180,71 C dan dekomposisi air ligan pada suhu 216,15-263,18 C. Spektrofotometer FTIR menunjukkan adanya ikatan v(Co-N) dan v(Co-OH2) pada bilangan gelombang 503,44 cm-1 dan 419,57 cm-1. Uji toksisitas senyawa ini dilakukan dengan metode Brine Shrimp Lethality Test (BSLT) dan dihasilkan nilai toksisitas LC50 ligan 2(4-klorofenil)-4,5-difenil-1H-imidazol dan kompleks Co(II) sebesar 23,71 ppm dan 59,70 ppm. ==================================================================================================== Cobalt(II) complex compound with 2(4-chlorophenyl)-4,5-diphenyl-1H-imidazole ligand has been synthesized using reflux method. The yield of the complex is 65.29%. The violet crystal was absorbed at 445 nm. The complex was characterized by CHN elemental analyzer with the results C=61.038%, H=5.174% and N=6.779%. Characterization of metal ion by AAS obtained Co(II)=7.146%. Based on these values, the proposed structure of the complex compound is octahedral and the proposed molecular is Co(II)[2(4-chlorphenyl)-4,5-diphenyl-1H-Imidazoel]2(H2O)4∙2H2O. The structural formula is supported by the analysis of TGA that showed crystal water decomposition at 160.5-180.71 °C and ligand water decomposition at 216.15-263.18 °C. The IR spectrum showed the characteristic of v(Co-N) and v(Co-OH2) at 503.44cm-1 and 419.57 cm-1. Toxicity test was observed by Brine Shrimp Lethality Test (BSLT) method revealed the LC50 of the ligand and the complex are 23.71 ppm and 59.70 ppm.
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