Hubungan Antara HBA1C dengan Profil Lipid Pada Pasien Diabetes Melitus Tipe 2 Di Rumah Sakit Universitas Kristen Indonesia
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Institusion
Universitas Kristen Indonesia
Author
Tandirerung, Juan Bill Nehemia
Subject
Diseases of the blood and blood-forming organs
Datestamp
2020-10-15 07:46:38
Abstract :
Latar Belakang: Diabetes Melitus merupakan penyakit metabolik dengan karakteristik hiperglikemia akibat kelainan sekresi insulin, resistensi insulin, maupun keduanya. HbA1c mampu merefleksikan rata-rata glukosa darah 2-3 bulan terakhir. Kontrol glikemik yang buruk sering menunjukkan kelainan profil lipid dan berisiko mengalami komplikasi kardiovaskular. Tujuan Penelitian: Mengetahui hubungan antara kadar HbA1c dengan profil lipid pada pasien DM tipe 2. Metode: Penelitian bersifat analitik dengan pendekatan potong lintang pada 52 pasien DM tipe 2 di Rumah Sakit Universitas Kristen Indonesia periode September 2017 ? September 2018. Hasil: Dari 52 subjek peneltian, 25(48.1%) perempuan dan 27(51.9%) laki-laki. Usia rata-rata subjek penelitian adalah 57,67 tahun. Rata-rata dan standar deviasi HbA1c, HDL, LDL, trigliserida, dan kolesterol total adalah 9,76±2,3, 48,31±8,9, 175±53,6, 170±63,6, dan 219,6±62,1 secara berurutan. Hasil menunjukkan korelasi yang signifikan antara HbA1c dengan LDL (p<0,05 r=0,307), kolesterol total (p<0,05 r=0,291), dan trigliserida (p<0,05 dan r=0,343) secara berurutan. Terdapat korelasi yang tidak signifikan antara HbA1c dan HDL (p>0,05 r=-0,206) Kesimpulan: Pada pasien diabetes, peningkatan HbA1c diikuti dengan peningkatan kolesterol total, LDL, trigliserida dan penurunan HDL. Kata Kunci: Diabetes Melitus, HbA1c, profil lipid Background: Diabetes Mellitus (DM) is a metabolic disease with hyperglycemic characteristic due to abnormalities of insulin secretion, insulin resistance or both. HbA1c could describe last 2-3 months blood glucose average. Poor glycemic control often shows abnormalities on their lipid profile and have cardiovascular complication risks. Research purpose: Search lipid protein various levels of HbA1c on DM type 2 patients. Method: The analytical research was conducted using cross sectional approach on 52 patients of DM type 2 at Indonesia Christian University Hospital during September 2017 ? September 2018. Result: From 52 subjects, 25(48.1%) subjects are female and 27(51,9%) subjects are male. The average age of subjects are 57,67 years old. The values (mean±SD) of HbA1c, HDL, LDL, triglyceride, and total cholesterol were: 9,76±2,3, 48,31±8,9, 175±53,6, 170±63,6, and 219,6±62,1, respectively. Significantly correlation were found between HbA1c with LDL cholesterol (p<0,05 r=0,307), total cholesterol (p<0,05 r=0,29), and triglyceride (p<0,05 r=0,343) respectively. There was no siginificant correlation between HbA1c and HDL cholesterol (p>0,05 r=-0,206). Conclusion: In diabetic patient increased of HbA1c levels was also observed to be increased in total cholesterol, LDL, triglyceride, and decreased of HDL cholesterol level. Keywords: Diabetes Mellitus, HbA1c, Lipid Profile.
Latar Belakang: Diabetes Melitus merupakan penyakit metabolik dengan karakteristik hiperglikemia akibat kelainan sekresi insulin, resistensi insulin, maupun keduanya. HbA1c mampu merefleksikan rata-rata glukosa darah 2-3 bulan terakhir. Kontrol glikemik yang buruk sering menunjukkan kelainan profil lipid dan berisiko mengalami komplikasi kardiovaskular. Tujuan Penelitian: Mengetahui hubungan antara kadar HbA1c dengan profil lipid pada pasien DM tipe 2. Metode: Penelitian bersifat analitik dengan pendekatan potong lintang pada 52 pasien DM tipe 2 di Rumah Sakit Universitas Kristen Indonesia periode September 2017 ? September 2018. Hasil: Dari 52 subjek peneltian, 25(48.1%) perempuan dan 27(51.9%) laki-laki. Usia rata-rata subjek penelitian adalah 57,67 tahun. Rata-rata dan standar deviasi HbA1c, HDL, LDL, trigliserida, dan kolesterol total adalah 9,76±2,3, 48,31±8,9, 175±53,6, 170±63,6, dan 219,6±62,1 secara berurutan. Hasil menunjukkan korelasi yang signifikan antara HbA1c dengan LDL (p<0,05 r=0,307), kolesterol total (p<0,05 r=0,291), dan trigliserida (p<0,05 dan r=0,343) secara berurutan. Terdapat korelasi yang tidak signifikan antara HbA1c dan HDL (p>0,05 r=-0,206) Kesimpulan: Pada pasien diabetes, peningkatan HbA1c diikuti dengan peningkatan kolesterol total, LDL, trigliserida dan penurunan HDL. Kata Kunci: Diabetes Melitus, HbA1c, profil lipid Background: Diabetes Mellitus (DM) is a metabolic disease with hyperglycemic characteristic due to abnormalities of insulin secretion, insulin resistance or both. HbA1c could describe last 2-3 months blood glucose average. Poor glycemic control often shows abnormalities on their lipid profile and have cardiovascular complication risks. Research purpose: Search lipid protein various levels of HbA1c on DM type 2 patients. Method: The analytical research was conducted using cross sectional approach on 52 patients of DM type 2 at Indonesia Christian University Hospital during September 2017 ? September 2018. Result: From 52 subjects, 25(48.1%) subjects are female and 27(51,9%) subjects are male. The average age of subjects are 57,67 years old. The values (mean±SD) of HbA1c, HDL, LDL, triglyceride, and total cholesterol were: 9,76±2,3, 48,31±8,9, 175±53,6, 170±63,6, and 219,6±62,1, respectively. Significantly correlation were found between HbA1c with LDL cholesterol (p<0,05 r=0,307), total cholesterol (p<0,05 r=0,29), and triglyceride (p<0,05 r=0,343) respectively. There was no siginificant correlation between HbA1c and HDL cholesterol (p>0,05 r=-0,206). Conclusion: In diabetic patient increased of HbA1c levels was also observed to be increased in total cholesterol, LDL, triglyceride, and decreased of HDL cholesterol level. Keywords: Diabetes Mellitus, HbA1c, Lipid Profile.
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