Efek Pemberian Ekstrak Daun Sirsak Terhadap Kadar
Vascular Cell Adhesion Molecule-1 Serum pada Hewan
Model Kanker Kolorektal
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Institusion
Universitas Kristen Indonesia
Author
Lumbantoruan, Irma Rebina Romauli
Subject
MEDICINE
Datestamp
2024-10-21 04:19:01
Abstract :
Annona muricata (tanaman sirsak) digunakan oleh masyarakat Indonesia sebagai obat herbal dalam mengobati berbagai penyakit. Bagian tanaman sirsak yang diketahui memiliki efek antikanker adalah daun sirsak. Vascularcell Adhesion Molecule-1 (VCAM-1) adalah glikoprotein permukaan sel endotel pembuluh darah yang diaktifkan oleh sitokin mediator inflamasi. Molekul adhesi ini memiliki interaksi dengan sel tumor. Penelitian ini bertujuan untuk mengetahui efek ekstrak daun sirsak (A. Muricata) terhadap berat badan dan kadar serum VCAM-1 pada hewan model karsinogenesis kolorektal. Hasil penelitian diuji menggunakan independent sample t- test. Berdasarkan penelitian yang telah dilakukan, berat badan hewan model karsinogenesis kolorektal selama 8 minggu mengalami peningkatan. Namun peningkatan tidak bermakna (p=0,774) jika dibandingkan antara kelompok kontrol dan perlakuan. Ekstrak daun sirsak (A.muricata) tidak menurunkan konsentrasi serum VCAM-1 secara bermakna (p=0,419). Namun demikian, ekstrak air A.muricata telah menurunkan konsentrasi serum VCAM-1 sebesar 27%. Kata Kunci : Annona muricata, Obat herbal, Vascularcell Adhesion Molecule-1, karsinogenesis, Independent sample t-test. / Tradisionally, Annona muricata (sirsak) is used as a herbal medicine. People used the leave as tea drink to help curing several diseases, include cancer. Vascularcell Adhesion Molecule-1 (VCAM-1) is glycoprotein of cell endothelium activated by cytokin. This adhesion molecule has an interaction on cancer cell. The purpose of this study is to investigate the effect of A. muricata extract on weight and concentration of serum VCAM-1 in colon carcinogenesis model. This study data was analized using independent sample t-test methode. Animal?s weight increased during 8 weeks study in both groups. This increased is not significant (p=0,774) between control and treatment groups. The A.muricata extract water has no significant (p=0,419) on VCAM-1 serum concentration. However, A. muricata extract water decreased VCAM-1 serum concentration about 27%. Keywords : Annona muricata, herbal medicine, Vascularcell Adhesion Molecule-1, carcinogenesis, Independent sample t-test.
Annona muricata (tanaman sirsak) digunakan oleh masyarakat Indonesia sebagai obat herbal dalam mengobati berbagai penyakit. Bagian tanaman sirsak yang diketahui memiliki efek antikanker adalah daun sirsak. Vascularcell Adhesion Molecule-1 (VCAM-1) adalah glikoprotein permukaan sel endotel pembuluh darah yang diaktifkan oleh sitokin mediator inflamasi. Molekul adhesi ini memiliki interaksi dengan sel tumor. Penelitian ini bertujuan untuk mengetahui efek ekstrak daun sirsak (A. Muricata) terhadap berat badan dan kadar serum VCAM-1 pada hewan model karsinogenesis kolorektal. Hasil penelitian diuji menggunakan independent sample t- test. Berdasarkan penelitian yang telah dilakukan, berat badan hewan model karsinogenesis kolorektal selama 8 minggu mengalami peningkatan. Namun peningkatan tidak bermakna (p=0,774) jika dibandingkan antara kelompok kontrol dan perlakuan. Ekstrak daun sirsak (A.muricata) tidak menurunkan konsentrasi serum VCAM-1 secara bermakna (p=0,419). Namun demikian, ekstrak air A.muricata telah menurunkan konsentrasi serum VCAM-1 sebesar 27%. Kata Kunci : Annona muricata, Obat herbal, Vascularcell Adhesion Molecule-1, karsinogenesis, Independent sample t-test. / Tradisionally, Annona muricata (sirsak) is used as a herbal medicine. People used the leave as tea drink to help curing several diseases, include cancer. Vascularcell Adhesion Molecule-1 (VCAM-1) is glycoprotein of cell endothelium activated by cytokin. This adhesion molecule has an interaction on cancer cell. The purpose of this study is to investigate the effect of A. muricata extract on weight and concentration of serum VCAM-1 in colon carcinogenesis model. This study data was analized using independent sample t-test methode. Animal?s weight increased during 8 weeks study in both groups. This increased is not significant (p=0,774) between control and treatment groups. The A.muricata extract water has no significant (p=0,419) on VCAM-1 serum concentration. However, A. muricata extract water decreased VCAM-1 serum concentration about 27%. Keywords : Annona muricata, herbal medicine, Vascularcell Adhesion Molecule-1, carcinogenesis, Independent sample t-test.
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