Abstract :
Centralized medicine is medicine that will be given to patients where the management of the medicine is completely handed over to the nurse, so that the use of medicine can really be controlled by the nurse to avoid the risk of loss, both material and non-material, so that it can be minimized. The aim of research was to determine nurses' knowledge about the implementation of drug centralization in inpatient rooms P1 and P2. This research is a non-experimental quantitative research with the research method chosen, namely the exploratory descriptive method. The population was all 106 nurses with a sample size of 51 respondents using a purposive sampling technique, data collection using a questionnaire sheet. This research was conducted at the Otanaha Regional General Hospital, Gorontalo City, with the research period from May-July 2023. The highest level of good knowledge was 35 respondents (58.6%) on average who understood the implementation of drug centralization. The results of the research regarding the relationship between nurses' knowledge and the application of drug centralization have a confidence level of 95% and the Chi-Square results show that the p value is 0.000, which is smaller (p < a 0.05), which means there is a relationship between nurses' knowledge and the application of centralization. So it can be concluded that nurses' knowledge regarding the application of drug centralization is stated to have a significant level, which means there is a relationship between the two variables.