UJI STABILITAS NANOSTRUCTURED LIPID CARRIER (NLC)
MELOXICAM DENGAN KOMBINASI LIPID PADAT (Glyceril
monostearate) DAN LIPID CAIR (Caprylic triglyceride)
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Institusion
Universitas PGRI Adi Buana Surabaya
Author
AISYAH, DEWI SHABRINA
Subject
R Medicine (General)
Datestamp
2022-11-17 07:13:24
Abstract :
Dewi Shabrina Aisyah The stability test of Meloxicam Nanostructured Lipid Carrier (NLC) at 25°C was declared stable because it did not undergo physical and chemical changes during storage. Meloxicam has a log P of 3.43 meaning low solubility in water. NLC is an extension of SLN and consists of solid lipids and liquid lipids. To increase the bioavailability of the preparation, the drug design in the form of NLC was developed. This study aims to determine the effect of differences in samples stored at 25°C and 40°C from organoleptic tests, pH, particle size, and entrapment efficiency. In the organoleptic test at 25°C, stable results were obtained and at 40°C there was a change in color and consistency for the NLC system. Preparation of NLC by selecting solid lipid Glyceryl monostearate (GMS), liquid lipid Caprylic triglyceride, and surfactant Tween 80. Organoleptic test at 40°C showed a change in color and consistency and at 25°C showed ideal results for the NLC system, pH value which is produced at a temperature of 25°C and 40°C meets the skin pH range of 4.5-6.5, the value of the particle size that meets the particle size range of 10-1000 nm is at a temperature of 25°C on day 0 (462.36 nm) and at a temperature of 40°C on all days that did not meet the particle size range, the entrapment efficiency test values that met the trapping efficiency range of 80-99% were produced at a temperature of 25°C on day 14 (89.2%), 28 ( 86.70%), and 56% (89.25%), and at a temperature of 40°C on day 0 (88.4%), 28 (88.12%), and 56 (88.56%) . Statistical test using Two Way ANOVA with Minitab 16.0 software on the entrapment efficiency test showed a value (p < 0.05) meaning there was a significant change. Keyword : Meloxicam, Nanostructured Lipid Carrier (NLC), Stability.
Dewi Shabrina Aisyah The stability test of Meloxicam Nanostructured Lipid Carrier (NLC) at 25°C was declared stable because it did not undergo physical and chemical changes during storage. Meloxicam has a log P of 3.43 meaning low solubility in water. NLC is an extension of SLN and consists of solid lipids and liquid lipids. To increase the bioavailability of the preparation, the drug design in the form of NLC was developed. This study aims to determine the effect of differences in samples stored at 25°C and 40°C from organoleptic tests, pH, particle size, and entrapment efficiency. In the organoleptic test at 25°C, stable results were obtained and at 40°C there was a change in color and consistency for the NLC system. Preparation of NLC by selecting solid lipid Glyceryl monostearate (GMS), liquid lipid Caprylic triglyceride, and surfactant Tween 80. Organoleptic test at 40°C showed a change in color and consistency and at 25°C showed ideal results for the NLC system, pH value which is produced at a temperature of 25°C and 40°C meets the skin pH range of 4.5-6.5, the value of the particle size that meets the particle size range of 10-1000 nm is at a temperature of 25°C on day 0 (462.36 nm) and at a temperature of 40°C on all days that did not meet the particle size range, the entrapment efficiency test values that met the trapping efficiency range of 80-99% were produced at a temperature of 25°C on day 14 (89.2%), 28 ( 86.70%), and 56% (89.25%), and at a temperature of 40°C on day 0 (88.4%), 28 (88.12%), and 56 (88.56%) . Statistical test using Two Way ANOVA with Minitab 16.0 software on the entrapment efficiency test showed a value (p < 0.05) meaning there was a significant change. Keyword : Meloxicam, Nanostructured Lipid Carrier (NLC), Stability.
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